A thought came to mind as I read your post. How is your autofocus set up? Are you using “area” or “zone” with multiple points…or are you using a single point? You might get away with area for close shots, but at distance the focus gets much more critical. I’d be using “point” and shooting for the eye.

BTW, your 5D is well capable of Astro photography. It doesn’t take as much ISO as you think to shoot the Milky Way. I’d use only as much ISO as I need to keep the shutter at around 30sec.

Last edited by ChrisF; 03/10/22.