My son shoots a Ruger M77 Mark II in .25-06 that seems to shoot everything well. We settled on a 120 Speer BTSP because it has a decent BC, is cheap so he could shoot a bunch and I have no complaints on terminal performance for deer/antelope/coyotes.
Mine is a Winchester 70 with a McGowen 1:9. I thought the faster twist would help increase the odds of shooting the heavies better but it seems to prefer stuff closer to 100 grains. The 100 Speer flat base seems to work just fine and scoots right along.
It used to be a .257 AI that got .25-06 velocities. The 100 grain SGK shot well and killed stuff dead but didn't penetrate as well as I would like so you had to be a little careful on placement. Worked great behind the shoulder.