About 30 years ago, a buddy of mine bought a Desert Eagle in 44, it was entertaining to shoot, and it shot well, but neither of us could figure out how to carry the thing comfortably for deer hunting. Granted, that was a long time ago, and lots of custom holster makers are doing great things today, but back then, it was just awkward, to say the least, and neither of us had big hands, either, so they simply didn't fit very well. He sold it pretty soon afterwards.
I had a custom shortened Ruger SBH that fit in a holster and was easy to pack around, so I didn't mourn the sale of his pistol at all. I already had a good packin' gun.
