I realize there are different applications, but there seems to be a ton of overlap. Even if we just look at 6.5 size calibers, can't computer simulations actually tell you what the best design would be?
No.
There’s way to many variables. From wind velocity, to range, to target size and toughness (if an animal) to an individual shooters ability to handle recoil, the need for rapid follow up shots, the size and weight of the firearm, and on and on.
