Tough to beat a 30-06 with 180 grain partitions for most plains game. A 300 win with 200g partitions or a frames is also a good way to go. The places I hunted rarely offered shots beyond 250 but it was Northern transval near potgietersrus once and near warm baths or Bela Bela the other time. Eastern cape or Namibia can offer longer shots. Last time I took a 375 ruger with 260 grain NABs and a 300 wsm with 165g interbonds.

That old 165g interbond load of mine was great on deer and elk but I ended up just using the 375 ruger to go 5 for 5. Five one shot kills no misses but I wasn't very recoil sensitive at the time. Next time I'll probably take a 30-06 with 180 or 200 grain partitions unless I go somewhere that offers longer shots.

Bb