Dude270,
Why not? At home defense distances, subsonic 220 grain 300 BLK hits as hard as 44 mag ammo out of a 4 inch barreled revolver and nobody ever says that the 44 mag is not sufficient for home defense.
Having seen / dressed out several deer that were shot with subsonic heavy weight bullets from 300 B.O.'s , underwhelmed with performance would be an understatement. Yes, the deer died, but wound channels and damage was no where even close to the damage from a 44 mag, or even a .223 with hunting type bullets.
30 caliber heavyweights lack the frontal area of a 44 bullet, and, as said above, depend on yaw / tumbling instead of expansion to dump energy, and at 300 B.O. velocities don't seem to do much other than poke a hole.
The light weights, like the 110 VMax referenced above, work well at 300 BO speeds, expanding decently, but not fragmenting as much as they will at say 308 Win velocities.