We've been killing deer in S. Miss. for over 20 years with the .243 Win. I do the loading for the family. We've used the Hornady 100gr. SP for most of that time. Typically with 4350 loads. Here is a link to the Hodgdon load data with 4350 and 4831 powders.

https://www.hodgdonreloading.com/reloading-data-center