I started out using Accutips in my 220f due to how accurate they are but I lost all confidence in the bullet after having to grid search for 2 different deer with no sign of blood. Another buck only went 50 yards on a death run but he was shot right through the heart but no pass through. When I opened him up, there was little bullet fragments all over the off shoulder. I switched to Federal Trophy Copper slugs and have not looked back.
I know a lot of people use the Accutip's with success but that was my experience, for what it is worth.