I've been substituting Universal for Unique for a long time for pistol loads (and Clays for Bullseye), because I stopped shotgunning and was left with scads of those powders. The several pounds of Unique (and Bullseye) get dipped into from time to time but not like as if I relied solely on them, and I may never have to actually seek out further alternatives.
Of course all that's a moot point because of the primer situation. You can have all the powder known to mankind but without primers you're screwed. My "lifetime" supply of primers, as judged two years ago, may not actually be a lifetime supply as my pistol shooting (and rifle shooting that requires pistol primers) ticked up dramatically since then...
