I started shooting FA 454's 30-35 years ago. Back then, I found best accuracy with full power loads - H110 and FA 260 grain jacketed bullets. I got that out of my system a long time ago and have no desire to do that again
You said you didn't need grizzly loads but want some thump - I like 4227 for less than full power loads and is about all I use any more in 454 and 480 Ruger.
HS6 is another good powder for mid-level loads.
I shoot mostly cast bullets in the 300 - 335 grain range. When I want lighter .452 bullets, I use 45 Colt loads.
