Straight wheelweights do very well if not pushed beyond 2200 in most calibers. At handgun impacts its generally too hard.

I would add, there is very little left to gain over 2200 with Cast in a Rifle for hunting. In a handgun, a FN wheel weight bullet of the old wheel weight variety, is a perfect killer at normal speeds even though it rarely expands as noted above. If you want expansion, then go softer and focus on Fit.
Lastly; I have seen far more problems with too hard than too soft when it comes hunting cast bullets considering both accuracy and terminal effects.
Fit is King and enough Lube is Queen. Powder Coat has put the Queen's realm within the reach of everyone. If your fit is right, Powder coat solves all the rest of the trip down the barrel problems.