My choice made long ago is the .35 Whelen, I've only used it for Whitetails it has always produce great results. I like the Whelen's ability to use a broad variety of bullets, cast, pistol bullets and jacketed. My deer load is one of Ken Waters Pet Loads, it uses a 200gr. Hornady RN bullet and IMR 3031. This load is incredibly accurate often producing 3 shot cloverleaf groups. I've only recovered one of these bullets from a whitetail, it was perfectly mushroomed and retained 66% of its original weight.