What animal are you asking about. I believe that in the US there are thousands of hunters that use multiple calibers depending upon species and location. An elk hunter on the west coast may use a different cartridge than a plains hunter. For Elk the 300WM has been the most popular for several years, followed by the 7mm magnums, the 30:06, 270 and possibly the .308 win. Many use the same for big whitetails and mule deer. Antelope I would guess the 270 win., 7mm mag and a number of smaller caliber cartridges.