I guess I'm kind of the odd man out here. I don't have any single shot pistols in either caliber, but I have several S&W revolvers in each. I am a big .41 magnum fan (I also like 16 gauge shotguns), but I honestly don't see a lot of difference in the two from a shooting standpoint with full-house loads. I'm finding that, anymore, I need to limit the amount of heavy-recoil handgun shooting I do or I will suffer a certain amount of joint pain. I will say that my 357 PD is in close contention with my 500 S&W for most unpleasant handgun to shoot award, but that's an outlier.
I was once asked, by a regional outdoor column newspaper guy, what handgun I'd choose if I could only have one and my reasoning. I told him my plain-vanilla, 6" 657 Smith. With a 220 grain cast bullet at 1000 - 1100 fps it would last almost forever and do 90% of what any rational person would want to do with a handgun.
