The 145 Silver Tip load has been excelent on wild hogs and exits in most cases in my experience. It is one fast killer and they fall and expire as if they were struck by lightening.
I have only used them at close range shooting hogs in a big ring trap. But it sure worked for me on broadside shoulder shots on hogs from beteween 100 and 200 pounds.
I cannot fathom how it would fail as a self defence load except it will exit if that's an issue.
