When I had a 375H&H (actually two of them) both used but two loads. A full-powered 300gr RN sighted 2" high at 100m was for hunting. Second load was a 220gr Taipan infront of 39gr AR2205 (sold as Hodgdon H4227 in the USA) for practice and plinking. The reduced load was spot on at 100m. A very handy combination and it gave the young teenagers at the range a buzz knowing they'd fired a 375H&H.
Cheers...
Con