I have changed my philosophy over the years. When I got started I was always chasing the prefect load. I went through a lot of components seeking the elusive .01 inch improvement. Today I decide what accuracy and velocity I will settle for and start working toward it. I usually check a couple of manuals and also Mule Deer's loads that work. Using that as a guide, I start about .05% low and work up using 4 shot groups until I see pressure or reach the max load. Then I pick the most accurate charge and tinker with depth. If the load meets my desired goal, I am done.