I just came across this excellent old post/thread. Well done to all!

and I want to tell you that I too have had great success with my 50-110 in my TC Encore on three Cape buffalo. ( Mine is necked down to a true .500 caliber so I could use the CEB 410 grain Raptor bullet at 1,950fps.) All three buffalo were standing broadside and each bullet was placed in the centre of the shoulder. The result was three one shot, DRT, kills. I will load them to 2,100 fps muzzle velocity next time I use it on Cape buffalo.