I like Okie's load with the 454424 Keith bullet, it runs about 950fps or so, and shoots really well in my 4 5/8" Blackhawk, on the order of 1.5" groups at 25 yards. Plenty for deer, and it shoots lights out.
You can roll a turd in peanuts, dip it in chocolate, and it still ain't no damn Baby Ruth.
