I have a S&W 25-2 6" 45LC lately I've been shooting 23.5grs of H110 behind a 270 gr Kieth style cast bullet . That load produced no extraction problems. But dang it kicks way to hard. So I dropped the charge by 2grs and its kicks just a little bit less. Why did I ever want to load that hot stuff? Any how I think I'll go back to 14 grs of Blue dot.