If you intend to hunt in a semi-populated area then the .223 is the best way to go. The neighbors of the landowner will appreciate the lower report, the 22-250 is significantly louder. I find my .223 good out to a 300 yards which should be plenty good for eastern woodchucks. May I suggest you consider buying the Blackhills ammo. Their 50 gr. Hornady Vmax backed by 26 gr. of H335 shoots extremely well in all three .223s we have tried. In addition, the performance of the Vmax is nothing short of spectacular. Good luck with the new rifle and good hunting.