I've shot a couple of Rugers with the TS upper, they are perfect on on a MK III 22/45. Sure makes for a light and fairly compact pistol. They are anodized alloy with a steel barrel liner. A few Mk III's I've tried had pretty decent triggers, but they won't compare to a Model 41 without some significant trigger work.

With a TS, a low profile holosight can be mounted or taken off in a minute.

A 41 would be great if you could find the lightweight field barrel as an option. Otherwise you'd be carrying a 44 ounce holster gun. But, I doubt you could do better accuracy wise and the triggers are generally excellent. My 41 with the 5" lightweight was very handy (it was shipped as a 5" lightweight). One of my buddies has it (I sold it to him in '72) and he ain't parting with it.

You're getting into some significant money at that point.