I second the V-max - I use Nosler Partitions in my 270WSM and they explode groundhogs. I never though a Partition would do that because most consider it a deer hunting bullet. The V-max is cheaper and does great job, I highly recommend. BTW I use only 32gr V-maxs in my Savage 204 and it always gets the job done + leaves the dog alittle something to shake lol. Another thing is the 22-250 is smokin fast compared to the 243, could be some of the difference your seeing. Let us know what works good for ya.