Once again I'll have to preface this with I don't know from mooses. All I can picture is BIG and then add some more size to that. I load the Hornady .41/210 XTP and like it. I don�t see much difference between it and the .41/210 Sierra. That 300g bullet sure has the weight and you sure are pushing it fast at 1421 (funny isn�t it that 1400fps is fast for us handgun guys where as that speed for the long gun guys isn�t even considered). I�m sure it will kill a moose. All the numbers are in the right place my concern would be in how long it takes the moose to figure that out.
One suggestion is to practice speed loading the T/C for a quick follow on shot if the beast doesn�t fall in place. It is a pretty easy drill. All the double rifle guys do it. Two extra round between the fingers of the weak hand. Shoot, break the action, slip one in with the weak hand, close, and shoot.
Don�t think you are nuts at all. Seems like you are taking a very measured approach to this, using good load development practices and looking for all the info you can get. For me it would be a 265g CPBT or BearTooth nothing else would even be considered. You�ll go with what you have the most confidence in be it jacketed, or Barnes X, or hard cast and that is what it comes down to. I�ll sure be waiting to hear how this turns out, almost as good as having that tag, naa who am I kidding I�m green with envy. I�ve never hunted moose but one of my guns went on a moose hunt and had a great old time, killed a moose in Maine.
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Handgun Hunter no more. STILL LOVE THOSE .41's