I've tried lots of combinations in the older 1 in 14 twist 250's. To date my most accurate load is 36.5 grains of H380 under a 100 grain Remington Core Loct bullet. I got the bullets as a "repackaged item" from Midway. I haven't cronographed the load but according to the new Nosler manual it should run about 2650. That's pretty close to factory Remington velocity that I have chronographed. H380 is not what's loaded in the factory ammo and after taking apart a factory load, I cannot come up with what powder is used. Whatever the powder, it's ball and weighs 34.9 grains. Factory ammo is still the best in my gun but H380 comes close. Anyone know what powder Remington uses? Proprietary I suppose.