I would go with the 270 Wea. I have experience with 3 MkVs in 270WM and all were superb shooters. A max load of R22 pushing 150 HDY FBILs at 3265 is heck on deer. The Wea factory ammo is very pricey, but loaded very well.
That said, I'd go with a 7RM before either of them. I have 3 in the safe right now, so I guess you could say I'm alittle biased
