86thecat,
I don't think so inasmuch as Woodleigh has tested that bullet extensively in all the 35 calibers...

I know my 9.3x62 with the 320 gr. bullets will punch through a buffalo 85% of the time or come to rest on the off side skin..It shoots all bullets from 250 to 320 gr. very accurately..It is a 1x14 twist and I am sure that is what Woodleigh worked with. I have been told that in short barreled guns it will not expand properly but I get conflicting reports on this..in my 26 inch tube it works great, but the 9.3x62 dotes on long tubes.

If you went to a 350 gr. or heavier bullet in the Whelen then your scenario would become a problem at some point..