I love Barnes 130s over Varget in 30-06 and .308. I get the best accuracy at ~3150 (53 grains Varget in 30-06) and ~2950 (44-46 grains Varget in .308).
I have seen guns that didn't care for TSXs but shot TTSXs extremely well. I have not seen a gun that would not shoot TTSXs well.
I like the Barnes 130s so well, and the performance is so uniformly excellent that I see no reason to ever load anything heavier. Out of about twenty deer over the last few years with the Barnes bullets we have yet to stop one in a deer, and we just this year recovered one. Oddly, it was the only deer the first shot did not stop. The guy shot it in the knee and I got the bullet out of the dirt behind the deer. It took another 14 hours to get the deer (had to stop over night).
