The ONLY rifle I have that stops deer "in their tracks" has been my 338WM with 200 or 225 grain bullets.
The farthest I've had a deer go after being hit in the chest was shot with my 30-06 and a Hornady 150 grain Interlock "cup & core" bullet.
The vast majority of my deer hunting has been with my "lucky rifle", a 257 Roberts. With 100 grain bullets, it's been as effective as the 30-06, and it's done it a lot more often.
This year, I'll be using my new Tikka T3 6.5X55. The bullet will be either a 140 grain Hornady SST or a Hornady 129 Interlock. It shoots both bullets very well.