I don't fully understand why the .444's are considered big bores, they are oversized handgun rounds..... Wouldn't trust one in africa on either plains or DG. That goes for the .450 as well.
I think a 300 gr bullet at 2200 fps will kill lots of things very nicely. I know mine will kill a caribou with a 270 gr Speer at 2100 fps
. Within reasonable range, it won't much matter whether it's a 180 gr at 2800 fps or a 300 gr at 2200 fps -- hit them in the right spot, and they will die promptly.
Dennis