Saw lots of good suggestions and agree with just about all of 'em. Some 22 centerfires prefer a flat based bullet versus a boat tail. I still say the 22-250 is one inherently accurate round. It was the first thing I started reloading over 20 years ago. I don't do much load testing of it anymore cause I'm busy on other projects. So now my go-to, do it all woodchuck load is 35.5 gr. of IMR-4320 with a 55 gr. Ballistic Tip. Only runs about 3570 fps out of my old Mod. 700 Varmint Special but it's so accurate and consistent that it's the only thing I've used for the last 4 or 5 years now. But there's a lot of other powders that work well with this cartridge. See what your rifle likes.