I shot a 740# moose at 20 feet with the 375 Ruger African, 260 AB, 81.8gr H-4350. Head shot knocked him cold, finisher offer to the neck from 5 feet did not exit, expanded flat. I will bring something stouter to Africa, Nosler 300 AB or partitions.
260 is accurate and an excellent whitetail bullet, but any 375 bullet will work on deer.I bet it would work great on leopard or lion. I wish Nosler would make a tipped partition, these take a lot of recoil abuse in the magazine and still shoot moa.

There is no retreat but in submission and slavery!