I never had any deer go out of sight before dropping and many dropped right now.
I was told by someone long ago that the .45 was too small but you can't prove it by me.
Don't ever look at energy figures, see what the gun does and you will be happy.
I have killed deer with everything you can think of and the .45 round ball will never take a back seat.
It will make a .30 carbine look sick, better compare to a much larger gun. I would say a .35 Rem and maybe better then a 30-06.
All that with no meat loss.