I use a 25-05 with 100g Sierra Game Kings or 115 Bergers if ranges is out to 600 yards. It has enough energy to deck a deer flat at that range and is really fast and flat for normal deer shots. A .270 will do it too but I prefer the very light recoil of the 25-06 so I can shoot hundreds of shots in practice without developing a flinch. I start flinching with about 10 rounds using a 140g .270 bullet. For example, this year I shot a few hundred rounds at prairie dogs out to 1000 yards a day before hunting season. As a result, I felt real confident in my shooting. On opening day, I shot a 500 yard antelope (DOA with 3 feet of penetration) with complete confidence.
