Have you picked up a new batch of retumbo or h1000 lately? I say this cause over at Longrangehunting.com the guys over there are saying new lots of these powders are causing them to drop charges as much as 3 grains over past loadings. These guys shoot alot of big cased stuff and burn alot of powder so I trust them.

Sounds like you know your 30-378's. I have one in a sako and it has good freebore but yet 110gr ret over a 180 would be a hot load in my gun. One of my good loads is 104 ret over a 200 ab for 3190fps.
I'm just wondering if the powder degrading you are seeing is possibly somewhat normal (never heard of this before) and that the loads are really close to being on "the edge" to start with??