Works great on game. I've got both a Winchester and Marlin in the 375 Win. I intended these to be bear/boar guns. I've only used the 220gr Hornady on game and have only shot a coupld deer so far. That bullet seems much tougher than ideal for deer but I think will be great on bear and boar. From reports I've read I think the 200gr Sierra is the choice if using it for deer.
I love the rifle/cartridge but from my limited experience with it and the 220 gr Hornady, I'd have to say it doesn't do any better than my 30-30's on deer.
