Have to agree with a few of the previous posters. I've shot a few deer with the 375 and I dearly love it. One of my favorites. However, I haven't noticed any difference in kills compared to my 30/30's. There might be a noticeable difference on larger game but like I said, I've only used it on deer. Like a few have also stated, the 200 grainers might be better than they've been given credit for. I can say that the 220 grainers work fine. Hope to try them on a bear or hog in the next few years. Now if I can only get StiknString to sell me that Marlin he got for a song a few years back....