I think it's kind of hard to make a bad choice with a 35 whelen if you follow a few basic guidelines. I don't think I would want to shoot under 225 grains at a big animal (elk, bear, moose, etc) unless it was a Barnes X bullet. I would also shy away from Sierras if I was going after a big animal as well (we've had too many core separations and wouldn't use it on anything other than a broadside deer). I've been using 250 Speers with total success and my brother has used Barnes X 225s and now Noslers Partitions without any problems. When in doubt go with a premium bullet or more bullet weight and you should be good to go.