I hunted South Africa earlier this year with a 300 WSM and 165 grain TSX bullets. I had eight one-shot kills on (3) impala, gemsbok, blesbok, kudu, wildebeest, and zebra. I recovered one bullet; the rest are still in orbit circling Earth somewhere.

I have nothing but praise for the combination. I personally believe that with a good bullet like the TSX, the 165 is a better choice than the 180.