Lately, I made the decision to pull the heavy bullets out of my Noveske and load it with a magazine full of 40-grain Ballistic Tips.
The 40s shoot about one-half inch higher at 50 yards, so they are fine for shooting if someone enters our bedroom ... or shooting down the hallway.
I've found the 40Ballistics to be quite frangible on prairie dogs and rock chucks. It's a fairly safe bet that their LACK of penetration would make them great for home defense work.
