I have a 1006, and have shot a few 4506's. As well as the 645/745 guns. Smith & Wesson makes a really, and I mean REALLY nice custom shop gun based on them which sells for about $2500.
Their only real "fault" is their weight. They handle recoil better than the 1911 guns, especially in the 10mm models.
They can be had with, or easily modified to take, fully adjustable sights and their triggers respond well to trigger jobs.
Heck, at a "very low price," I'd be sorely tempted to buy it myself. E