Lot to lot variation was the common feature of the slow Norma powders back in the day. When I shifted to MRP I was fortunate to buy the stock of a gunshop going out of business, and I am still shooting that lot of powder.
I also heard from a Swedish source that RL22 is MRP that doesn't make all the requirements, and it is more variable than MRP. I can't confirm this statement, but I develop fewer loads now a days. I am looking forward to the .26 Nosler when it becomes available.
jim