When I hunted Africa, I used a .300 with 200 gr. Part. I did not get and eland, due to a goof up on my part.. On the same trip, my pal shot a .338 with 250 Nosler part. He did well and so did I.. But I did find the 200 gr. shot though all of my game except one a blue wildabeast took a 200 gr. in the left shoulder as it faced me, and the bullet was found in the right rear leg... We did recover a number of .250's that did not shoot clear though.. But no game was lost with either..
