The 338F has the advantage of good factory ammo...if not using pistol bullets for plinking by handloaders, there is not meaningful different IMHO on game with regular hunting loads, IMHO.
The 338F like the 358 WCF - are no frills hammers. IIRC, Layne Simpson dumped an Elk at just over 300 yds...which realistically is farther than much game is presented and taken across NA.
Last edited by 65BR; 02/08/19.