60 - 64 gr have done great for me. 17 deer, from 70 - 250 yards. 60gr Barnes HP is my favorite. 64gr Win is good, too.
Let my buddy's 8yo son use my rifle, for his first hunt. Took his deer with 1 shot, through the neck, @ 235 yards. Dropped where it stood, 64 gr Win PSP.
My 9yo Grandson took his first deer, last season. 210 yards, dropped in it's tracks. 30 minutes later, 140 hog @ 155 yards, using 60 gr Barnes HP.
Shot placement is 90% of the equation. IMHO
I don't shoot boolets over 64 gr, not accurate in my rifle.
I found a box of 40 gr FMJ, same bullet used in .22WMRF.
Loaded them to 2000 fps for varmints. A .22 Supermag, blast to shoot and quiet. My pellet rifle is louder.
An old timer I know took 22-250 cases and primed them, and & seated a 22 pellet on top. He said it was super quiet.