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The NAD increased my dopamine levels was noticed immediately. Im 80, my neighbors call me the Everready bunny

This is the kind of outpatient medicine care Medicare should be doing, not sending out surveys to see how they are doing, or making deals with large insurance companies or refusing payments on prescription drugs.

I'd smoke dope every day if it didn't make me a dope. So I drink alcohol every day and am fat n lazy.

The studies I've read say that the cannabinoids attach to the cannabinoid receptors, starve the cancer cells, and cause apoptosis.

I’ve said it before and I’ll say it again. America would be a far healthier, better place if everyone incorporated some cannabis/hemp into their physiology. Mentally and physically. Out.

Again this depends on what you call cancer cells. Thats certainly a reasonable mechanism. I have a problem with the first assumptions. Whats cancer. Using cannabinoids doesn't change the basic hormone problem and any pain/bladder improvement would take far longer than finasteride, which works immediately.

A positive effect on blood pressure, but no one should get too excited... not much of a reduction.

I've read the study (and others) and while a statistically significant reduction was observed, the effect size was very small (i.e. the reduction in blood pressure was rather trivial, only 4.5 to 5 mm Hg)

John

Had Ashwagandha included in my herbal tincture formulas decades ago..
.. in terms of modern pharmaceuticals, said to have inducer effect
on GI and hepatic CYP450.
For prodrugs(activation by CYP450) and drugs(metab. by CYP450)
is there reasonable risk for adverse reaction or therapeutic failure respectively?

The popular St Johns Wort is known as a potent CYP450 inducer significantly
lowering blood plasma level of certain drugs. Ie; Warfarin efficacy is reduced ,
but in the case of another blood thinner; clopidogrel (prodrug)
University of Michigan Cardiovascular Center reports potential for
amplified efficacy/increased bleeding.

what ever help they got from it, is insignificant, compared to the gain in health etc. if everyone took probiotics. Dont even get me started on vitamins.

c450 can act as an inducer and inhibitor depends on which article you read. Biggest problem with all botanicals, depending on their state of preparation, can have several pharmacological outcomes. Ash can take up to 90 days to work. GABA works immediately and is dose related.
Take Benadryl 50-100 mg standard dose as an example. To high a dose for me, so I take a Tagamet to block the c450 at get the pharmacology of 100 Benadryl without the side effects. As a bonus I get histamine blockage from the Tagamet and no upset tummy.
I don't think on the street medicine is up to this type of prescribing. Non-compliance of therapeutic medicine is the number one drug problem in the US. Bet you've never heard that before. People will not take responsibility for their own disease/ilness.

Besides protein/peptide drugs the biggest change today is in the Microbiome, or how the microorganism's in the gut interact.

Both of these fields are under Bioinformatics which is using AI to correlate the information. A recent AI computer just passed the NY medical exam test.

Bacteria are your friend

St, Johns Wort has the biggest list of drug interactions I've ever come across. Wouldn't touch it.

Ash takes to long to work, up to 90 days, GABA works right now

Thanks, Smokepole.

Seriously, how old are you that you know WTF was going on in Vietnam? Or are you just regurgitating?

Animal lovers are claiming near miracle results with
a proclaimed anti cancer 'Benadryl/Tagamet protocol'.
Unfortunately it all seems to be based on personal stories
posted on Fakebook.
The H1/H2 receptor blocker effect of the abovementioned
does seem to reduce some cardinal signs of inflammation ,
which dog owners are quick to perceive as remission of
mast cell tumors common in dogs.

Interesting
I started using this combination 20 years ago when cimetidine first came out

While diphenhydramine is listed as an antihistamine, its primary pharmacology is in the lymphatic system working on T cells. So Im not surprised people are trying it for this.

The pharmacotherapeutics of a lot of drugs haven't been studied -no money in it. An example of one, which Im sure readers are familiar with is acetaminophen. Many speculations as to its analgesic action.

Hmmm?

I had a long lasting cough after a bout with the Corona this past winter. Also experienced a really itchy back at night before falling asleep, which started weeks after the tests came up negative. Perusing the internet in an attempt to find out if others were having the same itching symptom, I ran across an item that pointed to some anecdotal info from, of all places, a FB group of a couple of women that a Dr was investigating.

No mention of Tagamet, but their use of benadryl for some of their itching symptoms intrigued me, and they had been reporting a lessening of other long covid symptoms ( some reportedly due to mast cell issues) . We had some benadryl around the house so I took some with the hope of alleviating the itchy back. Lo and behold, the cough went away within a couple of days.

As you said, a sample of one, but I'm keeping the benadryl around for future use.

The largest users of diphenhydramine are mommies who use it to make their kids sleepy at bedtime. Blocks acetylcholine. No CNS effects. No barbiturate habituation.



Getting back to cannabinoids --- When they have been around as long as some of the mentioned drugs, have the safety record, and get a price range that's reasonable------ there will be a new drug out to take there place.

Currently they are a classic example of the placebo effect, with the addition of being something new and out of the ordinary