I shoot the 200 TTSX at 2700 FPS over TAC in my M99. I don't crimp and never got any bullet creep on rounds in the magazine in my tests. In 2020 I shot a cow elk right behind the shoulder with it and she didn't DRT, but rather ran...away from the closest trail. So I levered up three more shots as she ran, two of which went right through the lungs too. She fell, pretty much right where I reckon she'd have fallen anyway (about 70 yards run), but the point is the three follow-up rounds fed slick could be, even though they were loaded pretty close to max mag length anyway.
The 250s you plan to use will have a little more inertia, and I can't 100% accurately predict if they will move under recoil. Your degree of neck tension will also obviously affect the potential for the rounds to move.
As has been suggested earlier:
1) Test your handloads with rounds in the chamber to see if they move under recoil. If they do, crimp.
2) Crimp anyway if you feel like it, as it probably won't take you out of minute-of-moose.
Good luck and enjoy your hunt!
Rex