Not the .270 ones, but last year I loaded up some 120 TTSX in my 7mm Rem Mag. Stiff load of H100V and they're doing just under an inch at around 3450 FPS.
That load has so far taken a Bighorn Ram and a Mule Deer buck last year, this year a bighorn ewe, lamb and a big whitetail. No bullets have been recovered - the first shot on the ram hit just above the shoulder, exited just in front of the pelvis near the scrotum (we were considerably above it), traveled 2 1/2 feet of sheep, second shot at 300 yards was behind the shoulder.
Entrance wounds have been uniformly massive, exit wounds have been around an inch to an inch and a half. The ram made it furthest - 100 yards ish, though the first shot probably only nicked one lung (we boned it out the gutless way, so never saw the damage.) The ewe this year was hit behind the shoulder, took 2 steps and keeled over, blood painted all over the rocks - mule deer last year took one through the lungs, made it 10 yards, and tipped. Whitetail on wednesday was hit through lungs and heart and made it 30 yards.
I haven't yet hit a shoulder with this load - I would assume if you did, you'd lose most of the meat - but the bullets seem to stand up well to the velocity, and with a 2.5 inch zero at 100 M, my MPBR is nearing 350. I'm still waffling on whether I'd shoot an elk with this load - hunted them for a few days this year with the gun, would've taken a broadside shot, but not a shot through the shoulder, though I honestly think the bullet would stand up to it.
I'm still debating whether the velocity is necessary - it's nice to think that your only consideration has to be whether the animal is less than 350 yards, but so far the longest shot was the second shot on the ram at 300, and a 140 would have done that job equally well - and the meat damage can be excessive on the entrance wound, and if I'm not really using the full MPBR, then I'm not sure if the extra speed balances out the meat damage. But I've got no complaints about the bullets so far.