I've had assorted calibers that walk the pressure line in the Contender, including the .250/3000, 300savage, 6mmBR, 7mmBR, and a few others.
with .473 case heads such as the 22-250, keep pressure below 35K PSI and you are likely to have no problems with frame stretch.
go much past that, and you eventually have to scrap that one for parts.