Neck that Barrett down to .243 with a Premium 100 gr bullet, and yer good to go..
Or, one could learn to hunt, in preference to lobbing them out there...where practicable.
I have to admit, with a known, laser-ranged finding, and the 17 inch bbled '06, or the feather-weight 700TI bbled Rem 725 in .260, I'm ok out to 400 yards with a solid rest.. Not happy, just OK. (The last 9 caribou have gone 200, mostly 350 and out...some with the below, - tho lucky range sans range-finder guess don't hurt none either...)
I'll push the much customized 10 lb Mauser 98 in '06 with 27 inch heavy barrel to 500, ditto the (mostly) factory standard Ruger .338 WM. (I've ranged both to 700 - and I'm not going there - not on animals.
If the Leopold 800si range finder isn't reading it, I'm not shooting at it (it's good to 550 or so, under field conditions)... But then the ATV or snow machine is packing the Mauser wt., it's not a hiking rifle - and I'm not hiking more than 5 or 6 miles per day with the also 10 lb .338. (When one comes upon 10 lbs of steaming brown bear poo in heavy cover, it's a mite more comforting than that short-barreled '06, tho likely not much more effective if the fit hits the Shan... and either kills moose quite effectively).
As JJHack says, there's about 100 things can happen at long range. Only one is good.
With skill, practice, and time to set up the shot, one can cut the odds at long range somewhat. Until Murphy shows up. And the SOB will, at the most inconvenient of times.
My idea of the perfect shot is powder burns on the hide, but one must of course be prepared for something beyond that.... YMMV as to where that is.
My best shot to date was with the .338, pushing a hand loaded 275 gr Speer GS on a spike moose at 16 yards.... head, on, just under the chin into the spine. Damned near took his head off.... A bit of over-kill, perhaps.....